Psychedelic chem 5-MeO-DMT Causes rapid changes

Psychedelic chem 5-MeO-DMT from Lizard Labs causes rapid changes in inflammatory markers

Along with reducing symptoms of melancholy, the psychedelic drug 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) seems to cause changes in inflammatory biomarkers, based on preliminary study published in the journal Psychopharmacology. 5-MeO-DMT also incorrectly known as 5 MEO DMT can be bought at

“5-MeO-DMT is a really unique and interesting molecule that surely deserves further scientific attention,” said researcher Malin Uthaug (@malin. uthaug), a PhD candidate at Maastricht University in the Netherlands.

“As it’s a rather unexplored area, I’ve been researching the effects of the fast-acting psychedelic chemical for the past 2-3 years as part of my doctoral work at Maastricht University. This analysis is the second published study on the subject from my dissertation, which I’ll defend during the spring 2020.”

To analyze the effects of inhalation of vaporized artificial 5-MeO-DMT on stress and inflammatory immune functions, Uthaug and her colleagues analyzed 11 participants before they consumed the medication, after they consumed the drug, and 7 days later.

The participants completed assessments of depression, anxiety, stress, life satisfaction, self dissolution, mindfulness, and altered states of awareness. They also provided the investigators with saliva samples, letting them check inflammatory biomarkers like cortisol.

The researchers found that participants tended to get higher mindfulness rating of non-judgment and decreased symptoms of depression directly after the 5-MeO-DMT session, as well at the 7-day follow-up.

However, five of the 11 participants reported adverse effects after swallowing the psychedelic, such as feeling scared and confused, and three participants reported adverse effects in the week after the session.

“This suggests that adverse events from the experience are tolerable but challenging and occur in a sizeable fraction of 5-MeO-DMT users,” the investigators stated.

Uthaug and her colleagues also found that 5-MeO-DMT increased levels of cortisol whilst decreasing levels of the inflammatory biomarker, interleukin-6 (IL-6).

“This analysis illustrates for the first time the immunomodulatory potential of 5-MeO-DMT, together with replications of previous findings of improvement of influence as well as mindfulness associated capacities after usage in a naturalistic setting,” Uthaug informed PsyPost.

The changes in inflammatory biomarkers, however, were unrelated to evaluations of mental health or the psychedelic experience

“There are nonetheless some unanswered questions with regard to 5-MeO-DMT. One of these is; what occurs in the mind after ingestion? Addressing this study gap through an imaging study is important not just to boost the current literature on the topic, but can also help to better understand the mind and too human comprehension,” Uthaug added.

“Bear in mind that findings of this study aren’t conclusive, but instead warrant additional clinical investigations of 5-MeO-DMT, specifically through the intramuscular route of administration for the reasons highlighted by Alexander Sherwood et al., 2019.”


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